Factor VIII Polyclonal Antibody

F8 encodes coagulation factor VIII, which participates in the intrinsic pathway of blood coagulation; factor VIII is a cofactor for factor IXa which, in the presence of Ca+2 and phospholipids, converts factor X to the activated form Xa. F8 produces two alternatively spliced transcripts. Transcript variant 1 encodes a large glycoprotein, isoform a, which circulates in plasma and associates with von Willebrand factor in a noncovalent complex. This protein undergoes multiple cleavage events. Transcript variant 2 encodes a putative small protein, isoform b, which consists primarily of the phospholipid binding domain of factor VIIIc. This binding domain is essential for coagulant activity. DefectsF8 results in hemophilia A, a common recessive X-linked coagulation disorder.

The Factor VIII Polyclonal Antibody is a highly specific and sensitive immunological tool designed for the detection and quantification of Factor VIII in various biological samples. This antibody is produced by immunizing animals with purified Factor VIII protein, resulting in a polyclonal antibody that recognizes multiple epitopes on the target protein.

The Factor VIII Polyclonal Antibody exhibits exceptional affinity and selectivity towards Factor VIII, enabling accurate and reliable measurement of this critical coagulation factor. It has been extensively validated for use in various immunoassays, including enzyme-linked immunosorbent assays (ELISA), Western blotting, and immunohistochemistry.

This antibody is supplied as a liquid formulation, ensuring ease of use and convenience. It is provided in a ready-to-use format, eliminating the need for any additional preparation steps. The Factor VIII Polyclonal Antibody is compatible with a wide range of sample types, including plasma, serum, and cell lysates, making it suitable for diverse research applications.

With its exceptional sensitivity and specificity, the Factor VIII Polyclonal Antibody is an indispensable tool for researchers and clinicians involved in the study and diagnosis of coagulation disorders. Its reliable performance and consistent results make it an ideal choice for laboratories seeking accurate and reproducible measurements of Factor VIII levels.