Factor IX Polyclonal Antibody

F9(coagulation factor IX) encodes vitamin K-dependent coagulation factor IX that circulates in the blood as an inactive zymogen. This factor is converted to an active form by factor XIa, which excises the activation peptide and thus generates a heavy chain and a light chain held together by one or more disulfide bonds. The role of this activated factor IX in the blood coagulation cascade is to activate factor X to its active form through interactions with Ca+2 ions, membrane phospholipids, and factor VIII. Alterations of F9, including point mutations, insertions and deletions, cause factor IX deficiency, which is a recessive X-linked disorder, also called hemophilia B or Christmas disease. Alternative splicing results in multiple transcript variants encoding different isoforms that may undergo similar proteolytic processing.

The Factor IX Polyclonal Antibody is a highly specific and reliable tool designed for the detection and quantification of Factor IX in various biological samples. This antibody is produced by immunizing animals with purified Factor IX protein, resulting in a polyclonal antibody that exhibits exceptional affinity and sensitivity towards its target.

The Factor IX Polyclonal Antibody is suitable for a wide range of applications, including Western blotting, immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). It has been extensively validated and proven to provide accurate and reproducible results, making it an indispensable tool for researchers and clinicians alike.

With its superior specificity, the Factor IX Polyclonal Antibody ensures minimal cross-reactivity with other proteins, ensuring reliable and precise detection of Factor IX. Its high affinity allows for the detection of even low levels of Factor IX, making it ideal for both qualitative and quantitative analysis.

The Factor IX Polyclonal Antibody is supplied as a ready-to-use solution, eliminating the need for time-consuming and complex preparation steps. Its long shelf life and stability ensure consistent performance, allowing for reliable and reproducible results over an extended period of time.

In summary, the Factor IX Polyclonal Antibody is a highly specific and reliable tool that offers exceptional sensitivity and accuracy in the detection and quantification of Factor IX. Its versatility and ease of use make it an invaluable asset for researchers and clinicians working in the field of coagulation disorders.