ERCC1 Polyclonal Antibody

The product of ERCC1 functions in the nucleotide excision repair pathway, and is required for the repair of DNA lesions such as those induced by UV light or formed by electrophilic compounds including cisplatin. The encoded protein forms a heterodimer with the XPF endonuclease (also known as ERCC4), and the heterodimeric endonuclease catalyzes the 5' incision in the process of excising the DNA lesion. The heterodimeric endonuclease is also involved in recombinational DNA repair and in the repair of inter-strand crosslinks. Mutations in this gene result in cerebrooculofacioskeletal syndrome, and polymorphisms that alter expression of ERCC1 may play a role in carcinogenesis. Multiple transcript variants encoding different isoforms have been found for this gene. The last exon of this gene overlaps with the CD3e molecule, epsilon associated protein gene on the opposite strand.

The ERCC1 Polyclonal Antibody is a highly specific and sensitive tool designed for the detection and quantification of ERCC1 protein expression in various biological samples. This antibody is produced using advanced immunization techniques, ensuring high affinity and specificity towards ERCC1.

ERCC1, also known as Excision Repair Cross-Complementation Group 1, plays a crucial role in the nucleotide excision repair pathway, which is responsible for repairing DNA damage caused by various factors such as UV radiation and chemical agents. Aberrant expression of ERCC1 has been implicated in several diseases, including cancer, making it an important target for research and diagnostic purposes.

The ERCC1 Polyclonal Antibody is validated for use in various applications, including Western blotting, immunohistochemistry, and immunofluorescence. It exhibits excellent performance in detecting ERCC1 protein expression in a wide range of sample types, including cell lysates, tissue sections, and whole-cell extracts.

This antibody offers several advantages over other commercially available antibodies, including high sensitivity, low background noise, and reproducibility. It has been extensively tested and validated to ensure consistent and reliable results. Additionally, it is provided in a convenient liquid format, allowing for easy handling and storage.

The ERCC1 Polyclonal Antibody is an essential tool for researchers and clinicians involved in studying DNA repair mechanisms, cancer biology, and personalized medicine. Its high specificity and sensitivity make it an ideal choice for investigating ERCC1 expression levels in various biological samples, aiding in the understanding of disease progression and treatment response.

Overall, the ERCC1 Polyclonal Antibody is a reliable and efficient tool that enables accurate detection and quantification of ERCC1 protein expression, facilitating advancements in research and clinical applications.