ErbB-4 Polyclonal Antibody

ERBB4 is a member of the Tyr protein kinase family and the epidermal growth factor receptor subfamily. It encodes a single-pass type I membrane protein with multiple cysteine rich domains, a transmembrane domain, a tyrosine kinase domain, a phosphotidylinositol-3 kinase binding site and a PDZ domain binding motif. The erb-b2 receptor tyrosine kinase 4 binds to and is activated by neuregulins and other factors and induces a variety of cellular responses including mitogenesis and differentiation. Multiple proteolytic events allow for the release of a cytoplasmic fragment and an extracellular fragment. Mutations in this gene have been associated with cancer. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized.

The ErbB-4 Polyclonal Antibody is a highly specific and sensitive tool designed for the detection and analysis of ErbB-4 protein expression in various biological samples. This antibody is produced using advanced recombinant DNA technology, ensuring high purity and consistency in every batch.

The ErbB-4 Polyclonal Antibody exhibits exceptional affinity and selectivity towards the ErbB-4 protein, making it an ideal choice for a wide range of applications, including Western blotting, immunohistochemistry, and immunofluorescence. Its superior sensitivity allows for the detection of even low levels of ErbB-4 expression, enabling accurate and reliable results.

This antibody has been extensively validated and characterized using various experimental approaches, ensuring its reliability and reproducibility. It has been shown to exhibit minimal cross-reactivity with other related proteins, further enhancing its specificity.

The ErbB-4 Polyclonal Antibody is supplied as a liquid formulation, ready for immediate use. It is provided in a convenient size, allowing for easy handling and storage. Each vial is carefully quality-controlled to ensure optimal performance and long-term stability.

With its exceptional specificity, sensitivity, and reliability, the ErbB-4 Polyclonal Antibody is an indispensable tool for researchers and scientists studying ErbB-4 protein expression and its role in various biological processes.