ErbB-3 Polyclonal Antibody

ERBB3 encodes a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases. This membrane-bound protein has a neuregulin binding domain but not an active kinase domain. It therefore can bind this ligand but not convey the signal into the cell through protein phosphorylation. However, it does form heterodimers with other EGF receptor family members which do have kinase activity. Heterodimerization leads to the activation of pathways which lead to cell proliferation or differentiation. Amplification of this gene and/or overexpression of its protein have been reported in numerous cancers, including prostate, bladder, and breast tumors. Alternate transcriptional splice variants encoding different isoforms have been characterized. One isoform lacks the intermembrane region and is secreted outside the cell. This form acts to modulate the activity of the membrane-bound form. Additional splice variants have also been reported, but they have not been thoroughly characterized.

The ErbB-3 Polyclonal Antibody is a highly specific and sensitive tool designed for the detection and analysis of ErbB-3 protein expression in various biological samples. This antibody is produced using advanced recombinant DNA technology, ensuring high purity and batch-to-batch consistency.

The ErbB-3 Polyclonal Antibody exhibits exceptional affinity and selectivity towards the ErbB-3 protein, making it an ideal choice for a wide range of applications, including Western blotting, immunohistochemistry, and immunofluorescence. It has been extensively validated and proven to provide reliable and reproducible results.

This antibody is supplied as a liquid formulation, ready for immediate use. It is provided in a convenient size, allowing for multiple experiments without the need for frequent reordering. The ErbB-3 Polyclonal Antibody is compatible with various sample types, including cell lysates, tissue homogenates, and serum.

With its superior performance and robustness, the ErbB-3 Polyclonal Antibody is an indispensable tool for researchers and scientists working in the fields of cancer biology, signal transduction, and drug discovery. Its exceptional sensitivity and specificity make it an invaluable asset in elucidating the role of ErbB-3 in various physiological and pathological processes.

Order the ErbB-3 Polyclonal Antibody today and unlock new insights into ErbB-3 protein expression and function. Experience the reliability and accuracy that this antibody offers, and accelerate your research towards groundbreaking discoveries.