ER81 Polyclonal Antibody

ETV1 encodes a member of the ETS (E twenty-six) family of transcription factors. The ETS proteins regulate many target genes that modulate biological processes like cell growth, angiogenesis, migration, proliferation and differentiation. All ETS proteins contain an ETS DNA-binding domain that binds to DNA sequences containing the consensus 5'-CGGA[AT]-3'. The protein encoded by this gene contains a conserved short acidic transactivation domain (TAD) in the N-terminal region, in addition to the ETS DNA-binding domain in the C-terminal region. This gene is involved in chromosomal translocations, which result in multiple fusion proteins including EWS-ETV1 in Ewing sarcoma and at least 10 ETV1 partners (see PMID: 19657377, Table 1) in prostate cancer. In addition to chromosomal rearrangement, this gene is overexpressed in prostate cancer, melanoma and gastrointestinal stromal tumor. Multiple alternatively spliced transcript variants encoding different isoforms have been identified.

The ER81 Polyclonal Antibody is a highly specific and sensitive tool designed for the detection and analysis of ER81 protein expression in various biological samples. This antibody is produced using advanced immunization techniques, ensuring high affinity and specificity towards ER81.

The ER81 Polyclonal Antibody exhibits exceptional performance in a wide range of applications, including Western blotting, immunohistochemistry, and immunofluorescence. It enables researchers to investigate the role of ER81 in cellular processes and pathways, facilitating a deeper understanding of its biological functions.

With its superior sensitivity, this antibody allows for the detection of even low levels of ER81 protein, enabling accurate quantification and analysis. Its robust performance ensures reliable and reproducible results, making it an ideal choice for both basic research and clinical applications.

The ER81 Polyclonal Antibody is manufactured under stringent quality control measures, ensuring batch-to-batch consistency and reliability. It is supplied in a convenient and ready-to-use format, eliminating the need for time-consuming preparation steps.

In summary, the ER81 Polyclonal Antibody is a valuable tool for researchers seeking to investigate the expression and function of ER81 protein. Its high specificity, sensitivity, and reliability make it an indispensable asset in various research fields, including cancer biology, neuroscience, and developmental biology.