E2F-5 Polyclonal Antibody

The E2F transcription factor 5 encoded by E2F5 is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of cell cycle and action of tumor suppressor proteins and is also a target of the transforming proteins of small DNA tumor viruses. The E2F proteins contain several evolutionarily conserved domains that are present in most members of the family. These domains include a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation domain. This protein is differentially phosphorylated and is expressed in a wide variety of human tissues. It has higher identity to E2F4 than to other family members. Both this protein and E2F4 interact with tumor suppressor proteins p130 and p107, but not with pRB. Alternative splicing results in multiple variants encoding different isoforms.

The E2F-5 Polyclonal Antibody is a highly specific and sensitive tool designed for the detection and analysis of E2F-5 protein expression in various biological samples. This antibody has been rigorously validated and exhibits exceptional performance in a wide range of applications, including Western blotting, immunohistochemistry, and immunofluorescence.

The E2F-5 Polyclonal Antibody is produced using state-of-the-art techniques, ensuring high purity and batch-to-batch consistency. It has been affinity-purified from rabbit serum, resulting in a highly specific antibody that recognizes the E2F-5 protein with minimal cross-reactivity to other related proteins.

With its exceptional sensitivity, this antibody allows for the detection of even low levels of E2F-5 protein expression, making it an invaluable tool for researchers studying cell cycle regulation, DNA replication, and cell proliferation. Its versatility and reliability make it suitable for use in both basic research and clinical applications.

The E2F-5 Polyclonal Antibody is supplied as a liquid formulation, ready for immediate use. It is provided in a convenient size and concentration, ensuring cost-effectiveness and minimizing waste. Each batch is accompanied by a detailed datasheet, providing comprehensive information on the antibody's specificity, recommended dilutions, and storage conditions.

In summary, the E2F-5 Polyclonal Antibody is a highly reliable and specific tool for the detection and analysis of E2F-5 protein expression. Its exceptional sensitivity and versatility make it an essential component of any research or diagnostic laboratory working in the field of cell cycle regulation and DNA replication.