E2F-2 Polyclonal Antibody

E2F transcription factor 2 encoded by E2F2 is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of cell cycle and action of tumor suppressor proteins and is also a target of the transforming proteins of small DNA tumor viruses. The E2F proteins contain several evolutionally conserved domains found in most members of the family. These domains include a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation domain. This protein and another 2 members, E2F1 and E2F3, have an additional cyclin binding domain. This protein binds specifically to retinoblastoma protein pRB in a cell-cycle dependent manner, and it exhibits overall 46% amino acid identity to E2F1.

The E2F-2 Polyclonal Antibody is a highly specific and sensitive tool designed for the detection and quantification of E2F-2 protein in various biological samples. This antibody has been meticulously developed using advanced immunization techniques and exhibits exceptional affinity and selectivity towards E2F-2.

E2F-2 is a transcription factor that plays a crucial role in cell cycle regulation and is involved in the control of DNA replication and cell proliferation. Dysregulation of E2F-2 has been implicated in various diseases, including cancer. Therefore, accurate measurement of E2F-2 protein levels is of paramount importance in both basic research and clinical applications.

The E2F-2 Polyclonal Antibody offers outstanding performance in a wide range of experimental techniques, including Western blotting, immunohistochemistry, and immunofluorescence. It has been rigorously validated to ensure reliable and reproducible results, making it an indispensable tool for researchers and clinicians alike.

This antibody is produced using high-quality materials and undergoes stringent quality control measures to guarantee batch-to-batch consistency and optimal performance. It is supplied as a liquid formulation in a convenient size, allowing for easy handling and storage.

In summary, the E2F-2 Polyclonal Antibody is a superior reagent that enables accurate and precise detection of E2F-2 protein. Its exceptional specificity, sensitivity, and reliability make it an invaluable asset for researchers and clinicians working in the field of cell cycle regulation and related disciplines.