E2F-1 (Acetyl-Lys120) Polyclonal Antibody

The protein encoded by E2F1 (E2F transcription factor 1) is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of cell cycle and action of tumor suppressor proteins and is also a target of the transforming proteins of small DNA tumor viruses. The E2F proteins contain several evolutionally conserved domains found in most members of the family. These domains include a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation domain. This protein and another 2 members, E2F2 and E2F3, have an additional cyclin binding domain. This protein binds preferentially to retinoblastoma protein pRB in a cell-cycle dependent manner. It can mediate both cell proliferation and p53-dependent/independent apoptosis.

The E2F-1 (Acetyl-Lys120) Polyclonal Antibody is a highly specific and sensitive tool designed for the detection and analysis of E2F-1 protein acetylated at lysine 120. This antibody has been meticulously developed and validated to ensure optimal performance in various applications, including Western blotting, immunoprecipitation, and immunofluorescence.

The E2F-1 protein plays a crucial role in cell cycle regulation and is known to be acetylated at lysine 120, which affects its transcriptional activity. This polyclonal antibody has been raised against a synthetic peptide corresponding to the acetylated lysine 120 region of the E2F-1 protein, ensuring high specificity and affinity for the target.

With its exceptional sensitivity, this antibody allows for the detection of even low levels of acetylated E2F-1 protein in complex biological samples. Its versatility enables researchers to explore the role of E2F-1 acetylation in various cellular processes and disease states.

The E2F-1 (Acetyl-Lys120) Polyclonal Antibody has been rigorously tested and validated to ensure consistent and reliable results. It exhibits minimal cross-reactivity with other proteins, ensuring accurate and specific detection of acetylated E2F-1 protein.

This antibody is supplied as a liquid formulation, making it easy to handle and use in various experimental setups. It is provided in a convenient size, allowing for multiple experiments without compromising its quality and performance.

In summary, the E2F-1 (Acetyl-Lys120) Polyclonal Antibody is a valuable tool for researchers studying the role of E2F-1 acetylation in cellular processes and disease. Its high specificity, sensitivity, and versatility make it an essential component of any laboratory focused on understanding the intricate mechanisms of cell cycle regulation.