E2A Polyclonal Antibody

TCF3 (transcription factor 3) encodes a member of the E protein  (class I) family of helix-loop-helix transcription factors. E proteins activate transcription by binding to regulatory E-box sequences on target genes as heterodimers or homodimers, and are inhibited by heterodimerization with inhibitor of DNA-binding  (class IV) helix-loop-helix proteins. E proteins play a critical role in lymphopoiesis, and the encoded protein is required for B and T lymphocyte development. Deletion of TCF3 or diminished activity of the encoded protein may play a role in lymphoid malignancies. TCF3 is also involved in several chromosomal translocations that are associated with lymphoid malignancies including pre-B-cell acute lymphoblastic leukemia  (t (1; 19), with PBX1), childhood leukemia  (t (19; 19), with TFPT) and acute leukemia  (t (12; 19), with ZNF384). Alternatively spliced transcript variants encoding multiple isoforms have been observed for TCF3, and a pseudogene of TCF3 is located on the short arm of chromosome 9.

The E2A Polyclonal Antibody is a highly specific and sensitive antibody that has been designed to detect and quantify the expression of E2A protein in various biological samples. This antibody has been produced using high-quality polyclonal antibodies that have been purified and validated to ensure optimal performance in a range of applications, including Western blotting, immunohistochemistry, and immunofluorescence.

The E2A Polyclonal Antibody has been extensively tested and validated for its specificity and sensitivity, ensuring that it provides accurate and reliable results. It has been shown to detect E2A protein expression in a variety of tissues and cell types, including lymphoid and myeloid cells, as well as in various cancer cell lines.

This antibody is supplied in a convenient and easy-to-use format, making it ideal for use in a range of research applications. It is available in a range of sizes to suit different experimental needs, and is supplied with detailed instructions for use to ensure optimal results.

Overall, the E2A Polyclonal Antibody is a high-quality and reliable tool for detecting and quantifying E2A protein expression in a range of biological samples. Its specificity, sensitivity, and ease of use make it an ideal choice for researchers working in a variety of fields, including cancer research, immunology, and developmental biology.