Dok-3 Polyclonal Antibody

Dok-1, Dok-2 and Dok-3 are members of a class of "docking" proteins which contain multiple tyrosine residues and putative SH2 binding sites. Dok-1 associates with the Ras GTPase activating protein (Ras GAP) upon tyrosine phosphorylation. Dok-2 (also designated p56 Dok) has also been identified as a potential mediator of the effects of p210 Bcr-Abl. Dok-3 is an adapter involved in the recruitment of inhibitory molecules and is highly expressed in B cells and macrophages. Immunoreceptor-mediated cellular activation induces tyrosine phosphorylation of Dok-3. Upon phosphorylation, Dok-3 binds to 5' inositol phosphatase SHIP and the protein tyrosine kinase Csk. Dok-3 may play a significant role in the negative regulation of immunoreceptor signaling in hemopoietic cells.

The Dok-3 Polyclonal Antibody is a highly specific and reliable tool for the detection and analysis of Dok-3 protein expression in various biological samples. This antibody has been meticulously developed and rigorously validated to ensure optimal performance and accuracy in experimental settings.

The Dok-3 Polyclonal Antibody exhibits exceptional sensitivity and specificity, enabling precise identification and quantification of Dok-3 protein levels. It is designed to recognize endogenous levels of Dok-3 protein, making it an invaluable asset for researchers studying the role and function of Dok-3 in cellular processes.

This antibody is produced using state-of-the-art techniques, ensuring batch-to-batch consistency and reproducibility. It has been extensively tested in a variety of applications, including Western blotting, immunohistochemistry, and immunofluorescence, demonstrating its versatility and reliability across different experimental platforms.

The Dok-3 Polyclonal Antibody is supplied as a liquid formulation, allowing for easy and convenient handling. It is provided in a ready-to-use format, eliminating the need for time-consuming and complex preparation steps. The antibody is also available in different sizes to accommodate various experimental requirements.

With its exceptional performance characteristics and robust validation, the Dok-3 Polyclonal Antibody is an indispensable tool for researchers investigating the intricate mechanisms underlying cellular signaling pathways involving Dok-3. Its high specificity and sensitivity make it an ideal choice for accurate and reliable detection of Dok-3 protein expression in diverse biological samples.