DNA Ligase IV Polyclonal Antibody

The protein encoded by LIG4 is a DNA ligase that joins single-strand breaks in a double-stranded polydeoxynucleotide in an ATP-dependent reaction. This protein is essential for V(D)J recombination and DNA double-strand break (DSB) repair through nonhomologous end joining (NHEJ). This protein forms a complex with the X-ray repair cross complementing protein 4 (XRCC4), and further interacts with the DNA-dependent protein kinase (DNA-PK). Both XRCC4 and DNA-PK are known to be required for NHEJ. The crystal structure of the complex formed by this protein and XRCC4 has been resolved. Defects in this gene are the cause of LIG4 syndrome. Alternatively spliced transcript variants encoding the same protein have been observed.

The DNA Ligase IV Polyclonal Antibody is a highly specific and reliable tool for the detection and analysis of DNA Ligase IV protein. This antibody has been extensively validated for its exceptional performance in various applications, including Western blotting, immunohistochemistry, and immunofluorescence.

The DNA Ligase IV Polyclonal Antibody exhibits a high affinity and specificity towards the target protein, ensuring accurate and precise results. It has been meticulously developed and rigorously tested to ensure optimal performance and minimal cross-reactivity with other proteins.

This antibody is produced using state-of-the-art techniques and undergoes stringent quality control measures to guarantee batch-to-batch consistency and reproducibility. It is manufactured in compliance with the highest industry standards, ensuring its reliability and effectiveness in scientific research and diagnostic applications.

The DNA Ligase IV Polyclonal Antibody is supplied in a convenient and user-friendly format, allowing for easy handling and storage. It is provided in a liquid form, eliminating the need for reconstitution, and is stable for long-term storage at recommended temperatures.

With its exceptional specificity, reliability, and ease of use, the DNA Ligase IV Polyclonal Antibody is an indispensable tool for researchers and clinicians involved in DNA repair studies, cancer research, and genetic diagnostics.