Dematin Polyclonal Antibody

Dematin actin binding protein encoded by DMTN is an actin binding and bundling protein that plays a structural role in erythrocytes, by stabilizing and attaching the spectrin/actin cytoskeleton to the erythrocyte membrane in a phosphorylation-dependent manner. This protein contains a core domain in the N-terminus, and a headpiece domain in the C-terminus that binds F-actin. When purified from erythrocytes, this protein exists as a trimer composed of two 48 kDa polypeptides and a 52 kDa polypeptide. The different subunits arise from alternative splicing in the 3' coding region, where the headpiece domain is located. Disruption of this gene has been correlated with the autosomal dominant Marie Unna hereditary hypotrichosis disease, while loss of heterozygosity of DMTN is thought to play a role in prostate cancer progression. Alternative splicing results in multiple transcript variants encoding different isoforms.

The Dematin Polyclonal Antibody is a highly specific and reliable tool for the detection and analysis of dematin protein in various biological samples. This antibody has been extensively validated and exhibits exceptional sensitivity and specificity, ensuring accurate and reproducible results.

The Dematin Polyclonal Antibody is produced using state-of-the-art techniques, guaranteeing high purity and batch-to-batch consistency. It has been rigorously tested for cross-reactivity with other proteins to ensure minimal interference and reliable performance.

This antibody is suitable for a wide range of applications, including Western blotting, immunohistochemistry, and immunofluorescence. It is designed to recognize dematin protein in various species, making it versatile and adaptable to different experimental setups.

The Dematin Polyclonal Antibody is supplied in a convenient and ready-to-use format, eliminating the need for time-consuming preparation. It is provided in a liquid formulation, ensuring ease of use and minimizing the risk of sample contamination.

With its exceptional performance and reliability, the Dematin Polyclonal Antibody is an indispensable tool for researchers and scientists working in the field of cell biology and molecular biology. It enables accurate and precise detection of dematin protein, facilitating further understanding of its role in cellular processes and disease mechanisms.

Choose the Dematin Polyclonal Antibody for your research needs and unlock new insights into dematin protein function and regulation.