Cystatin B Polyclonal Antibody

The cystatin superfamily encompasses proteins that contain multiple cystatin-like sequences. Some of the members are active cysteine protease inhibitors, while others have lost or perhaps never acquired this inhibitory activity. There are three inhibitory families in the superfamily, including the type 1 cystatins (stefins), type 2 cystatins and kininogens. This gene encodes a stefin that functions as an intracellular thiol protease inhibitor. The protein is able to form a dimer stabilized by noncovalent forces, inhibiting papain and cathepsins l, h and b. The protein is thought to play a role in protecting against the proteases leaking from lysosomes. Evidence indicates that mutations in this gene are responsible for the primary defects in patients with progressive myoclonic epilepsy (EPM1). One type of mutation responsible for EPM1 is the expansion in the promoter region of this gene of a CCCCGCCCCGCG repeat from 2-3 copies to 30-78 copies.

The Cystatin B Polyclonal Antibody is a highly specific and sensitive tool designed for the detection and quantification of Cystatin B protein in various biological samples. This antibody is produced through a rigorous process, ensuring its high affinity and specificity towards Cystatin B.

Cystatin B, a member of the cystatin superfamily, plays a crucial role in regulating protease activity and maintaining proteostasis within cells. It is involved in various physiological and pathological processes, including inflammation, cancer, and neurodegenerative diseases.

The Cystatin B Polyclonal Antibody exhibits exceptional performance in a wide range of applications, including Western blotting, immunohistochemistry, and enzyme-linked immunosorbent assays (ELISA). Its superior sensitivity allows for the detection of even low levels of Cystatin B protein, enabling accurate and reliable quantification.

This antibody is manufactured using state-of-the-art techniques and undergoes stringent quality control measures to ensure batch-to-batch consistency and reproducibility. It is supplied as a liquid formulation, ready for immediate use, and is compatible with various sample types, including cell lysates, tissue homogenates, and serum.

With its exceptional specificity, sensitivity, and versatility, the Cystatin B Polyclonal Antibody is an indispensable tool for researchers and scientists studying the role of Cystatin B in various biological processes and diseases. Its reliable performance and consistent results make it an ideal choice for both basic research and clinical applications.