CYP2D6 Polyclonal Antibody

CYP2D6 encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. Cytochrome P450 2D6 localizes to the endoplasmic reticulum and is known to metabolize as many as 25% of commonly prescribed drugs. Its substrates include antidepressants, antipsychotics, analgesics and antitussives, beta adrenergic blocking agents, antiarrythmics and antiemetics. The gene is highly polymorphic in the human population; certain alleles result in the poor metabolizer phenotype, characterized by a decreased ability to metabolize the enzyme's substrates. Some individuals with the poor metabolizer phenotype have no functional protein since they carry 2 null alleles whereas in other individuals the gene is absent. CYP2D6 can vary in copy number and individuals with the ultrarapid metabolizer phenotype can have 3 or more active copies of the gene. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

The CYP2D6 Polyclonal Antibody is a highly specific and sensitive tool designed for the detection and quantification of CYP2D6 protein expression. This antibody is produced through a rigorous process, ensuring its high affinity and specificity towards the target protein.

CYP2D6, a member of the cytochrome P450 superfamily, plays a crucial role in the metabolism of a wide range of drugs, including antidepressants, antipsychotics, and beta-blockers. Therefore, accurate measurement of CYP2D6 protein levels is essential for understanding drug metabolism and optimizing therapeutic strategies.

The CYP2D6 Polyclonal Antibody exhibits exceptional performance in various applications, such as Western blotting, immunohistochemistry, and immunofluorescence. It recognizes both the native and denatured forms of CYP2D6, enabling reliable detection and quantification across different sample types.

With its high sensitivity and specificity, this antibody offers researchers and clinicians a valuable tool for studying drug metabolism, pharmacogenetics, and personalized medicine. Its reliable performance and reproducibility make it an indispensable asset in pharmaceutical research, clinical diagnostics, and therapeutic monitoring.

The CYP2D6 Polyclonal Antibody is supplied in a convenient format, ensuring ease of use and storage. It is manufactured under strict quality control standards, guaranteeing batch-to-batch consistency and reliability. Each vial is accompanied by a detailed datasheet, providing comprehensive information on the antibody's characteristics, recommended protocols, and storage conditions.

In summary, the CYP2D6 Polyclonal Antibody is a highly specific and sensitive tool that enables accurate detection and quantification of CYP2D6 protein expression. Its exceptional performance, versatility, and reliability make it an indispensable asset for researchers and clinicians in the fields of drug metabolism, pharmacogenetics, and personalized medicine.