CYP27A1 Polyclonal Antibody

CYP27A1 encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This mitochondrial protein oxidizes cholesterol intermediates as part of the bile synthesis pathway. Since the conversion of cholesterol to bile acids is the major route for removing cholesterol from the body, this protein is important for overall cholesterol homeostasis. Mutations in CYP27A1 cause cerebrotendinous xanthomatosis, a rare autosomal recessive lipid storage disease.

The CYP27A1 Polyclonal Antibody is a highly specific and reliable tool designed for the detection and quantification of CYP27A1 protein in various biological samples. This antibody has been extensively validated for its exceptional performance in immunohistochemistry (IHC), immunofluorescence (IF), and western blotting (WB) applications.

CYP27A1, also known as cytochrome P450 27A1, is a key enzyme involved in the metabolism of cholesterol and bile acid synthesis. It plays a crucial role in the conversion of cholesterol into bile acids, which are essential for the digestion and absorption of dietary fats. Dysregulation of CYP27A1 has been implicated in various diseases, including atherosclerosis, gallstone formation, and metabolic disorders.

The CYP27A1 Polyclonal Antibody has been meticulously developed using high-quality immunogens and advanced immunization techniques. It exhibits exceptional specificity towards CYP27A1, ensuring minimal cross-reactivity with other related proteins. This antibody demonstrates high sensitivity, enabling the detection of even low levels of CYP27A1 protein in complex biological samples.

In IHC applications, the CYP27A1 Polyclonal Antibody provides clear and reliable staining of CYP27A1 protein in tissue sections, allowing for precise localization and visualization of this important enzyme. In IF assays, this antibody enables the detection of CYP27A1 protein in various cell types, facilitating the study of its subcellular localization and distribution. Additionally, in WB experiments, the CYP27A1 Polyclonal Antibody exhibits strong and specific band signals, ensuring accurate quantification of CYP27A1 protein levels.

This CYP27A1 Polyclonal Antibody is supplied as a liquid formulation, making it convenient and ready-to-use for various experimental procedures. It is available in different sizes to accommodate different research needs. Each batch of this antibody undergoes rigorous quality control tests to ensure consistent and reliable performance.

In summary, the CYP27A1 Polyclonal Antibody is a highly specific and sensitive tool for the detection and quantification of CYP27A1 protein. Its exceptional performance in IHC, IF, and WB applications, along with its reliable and consistent quality, makes it an ideal choice for researchers studying the role of CYP27A1 in cholesterol metabolism, bile acid synthesis, and related diseases.