CYP26B1 Polyclonal Antibody

CYP26B1 (cytochrome P450 family 26 subfamily B member 1) encodes a member of the cytochrome P450 superfamily. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. The encoded protein is localized to the endoplasmic reticulum, and functions as a critical regulator of all-trans retinoic acid levels by the specific inactivation of all-trans retinoic acid to hydroxylated forms. Mutations in CYP26B1 are associated with radiohumeral fusions and other skeletal and craniofacial anomalies, and increased levels of the encoded protein are associated with atherosclerotic lesions. Alternative splicing results in multiple transcript variants.

The CYP26B1 Polyclonal Antibody is a highly specific and reliable tool designed for the detection and quantification of CYP26B1 protein in various biological samples. This antibody has been extensively validated for its exceptional performance in immunohistochemistry (IHC), immunofluorescence (IF), and western blotting (WB) applications.

CYP26B1, also known as cytochrome P450 26B1, is a key enzyme involved in the metabolism of retinoic acid (RA), a crucial signaling molecule in embryonic development, tissue homeostasis, and cellular differentiation. Dysregulation of CYP26B1 has been implicated in various pathological conditions, including cancer, autoimmune diseases, and developmental disorders.

The CYP26B1 Polyclonal Antibody has been meticulously produced using high-quality immunogens and advanced immunization techniques. It exhibits exceptional specificity towards CYP26B1, ensuring minimal cross-reactivity with other related proteins. This antibody demonstrates high sensitivity, enabling the detection of low-abundance CYP26B1 protein levels in complex biological samples.

In IHC applications, the CYP26B1 Polyclonal Antibody provides clear and reliable staining patterns, allowing for precise localization and visualization of CYP26B1 protein expression in tissue sections. In IF assays, this antibody enables the detection of CYP26B1 in various cell types, facilitating the investigation of its subcellular localization and dynamic changes in protein expression.

Furthermore, the CYP26B1 Polyclonal Antibody has been validated for WB applications, enabling the accurate quantification of CYP26B1 protein levels in cell lysates and tissue extracts. It exhibits excellent performance in detecting endogenous CYP26B1 protein, making it an invaluable tool for studying the regulation and function of CYP26B1 in diverse biological contexts.

In summary, the CYP26B1 Polyclonal Antibody is a highly reliable and specific reagent that enables the precise detection and quantification of CYP26B1 protein. Its exceptional performance in IHC, IF, and WB applications makes it an indispensable tool for researchers investigating the role of CYP26B1 in various physiological and pathological processes.