CYP26A1 Polyclonal Antibody

CYP26A1 encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This endoplasmic reticulum protein acts on retinoids, including all-trans-retinoic acid (RA), with both 4-hydroxylation and 18-hydroxylation activities. This enzyme regulates the cellular level of retinoic acid which is involved in regulation of gene expression in both embryonic and adult tissues. Two alternatively spliced transcript variants of CYP26A1, which encode the distinct isoforms, have been reported.

The CYP26A1 Polyclonal Antibody is a highly specific and reliable tool designed for the detection and quantification of CYP26A1 protein in various biological samples. This antibody has been extensively validated for its exceptional performance in immunohistochemistry (IHC), immunofluorescence (IF), and western blotting (WB) applications.

CYP26A1, also known as cytochrome P450 26A1, is a key enzyme involved in the metabolism of retinoic acid (RA), a crucial signaling molecule in embryonic development, tissue homeostasis, and cellular differentiation. Dysregulation of CYP26A1 has been implicated in various pathological conditions, including cancer, cardiovascular diseases, and developmental disorders.

The CYP26A1 Polyclonal Antibody has been meticulously produced using high-quality immunogens and advanced immunization techniques. It exhibits exceptional specificity towards CYP26A1, ensuring minimal cross-reactivity with other related proteins. This antibody offers superior sensitivity, enabling the detection of low-abundance CYP26A1 protein levels with high precision and accuracy.

In IHC applications, the CYP26A1 Polyclonal Antibody demonstrates excellent staining performance, providing clear and distinct localization of CYP26A1 protein within tissue sections. It is compatible with a wide range of sample types, including formalin-fixed paraffin-embedded (FFPE) tissues, frozen sections, and cell cultures.

For IF applications, this antibody enables precise visualization of CYP26A1 protein in various cellular compartments. It exhibits minimal background staining, ensuring reliable and reproducible results. Additionally, the CYP26A1 Polyclonal Antibody can be used in combination with other antibodies to study protein-protein interactions and co-localization studies.

In WB applications, the CYP26A1 Polyclonal Antibody recognizes the target protein with high specificity and sensitivity. It reliably detects endogenous CYP26A1 protein in cell lysates and tissue extracts, facilitating quantitative analysis of protein expression levels. The antibody exhibits minimal non-specific binding, ensuring accurate and reliable results.

Overall, the CYP26A1 Polyclonal Antibody is a valuable tool for researchers and scientists studying the role of CYP26A1 in various biological processes and diseases. Its exceptional specificity, sensitivity, and reliability make it an indispensable asset in the field of molecular biology and biomedical research.