Cyclin H Polyclonal Antibody

Cyclin H encoded by CCNH belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with CDK7 kinase and ring finger protein MAT1. The kinase complex is able to phosphorylate CDK2 and CDC2 kinases, thus functions as a CDK-activating kinase (CAK). This cyclin and its kinase partner are components of TFIIH, as well as RNA polymerase II protein complexes. They participate in two different transcriptional regulation processes, suggesting an important link between basal transcription control and the cell cycle machinery. A pseudogene of CCNH is found on chromosome 4. Alternate splicing results in multiple transcript variants.

The Cyclin H Polyclonal Antibody is a highly specific and reliable tool designed for the detection and analysis of Cyclin H protein in various biological samples. This antibody has been extensively validated and exhibits exceptional sensitivity and specificity, ensuring accurate and reproducible results.

Cyclin H is a crucial regulatory protein involved in cell cycle progression and transcriptional regulation. It forms a complex with CDK7, which is a component of the CDK-activating kinase (CAK) complex. This complex plays a pivotal role in the activation of CDKs, thereby controlling cell cycle transitions and gene expression.

The Cyclin H Polyclonal Antibody has been meticulously developed using advanced immunization techniques and state-of-the-art purification methods. It has been rigorously tested in a variety of experimental conditions, including Western blotting, immunoprecipitation, and immunofluorescence, to ensure its reliability and versatility.

With its high affinity and specificity, this antibody enables precise detection and quantification of Cyclin H protein levels in diverse sample types, such as cell lysates, tissue extracts, and whole-cell lysates. Its exceptional performance allows for accurate analysis of Cyclin H expression patterns and dynamics in various biological processes and disease states.

Furthermore, the Cyclin H Polyclonal Antibody exhibits minimal cross-reactivity with other related proteins, ensuring reliable and specific results. Its robust performance and consistent quality make it an ideal choice for researchers and scientists working in the fields of cell biology, molecular biology, and cancer research.

In summary, the Cyclin H Polyclonal Antibody is a highly reliable and specific tool for the detection and analysis of Cyclin H protein. Its exceptional sensitivity, versatility, and consistent performance make it an invaluable asset for researchers aiming to unravel the intricate mechanisms underlying cell cycle regulation and gene expression.