Cyclin E1 Polyclonal Antibody

Cyclin E1 encoded by CCNE1 belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK2, whose activity is required for cell cycle G1/S transition. Cyclin E1 accumulates at the G1-S phase boundary and is degraded as cells progress through S phase. Overexpression of CCNE1 has been observed in many tumors, which results in chromosome instability, and thus may contribute to tumorigenesis. Cyclin E1 was found to associate with, and be involved in, the phosphorylation of NPAT protein (nuclear protein mapped to the ATM locus), which participates in cell-cycle regulated histone gene expression and plays a critical role in promoting cell-cycle progression in the absence of pRB.

Introducing the Cyclin E1 Polyclonal Antibody, a cutting-edge scientific tool designed to facilitate accurate and reliable research in the field of cell cycle regulation. This high-quality antibody is meticulously crafted using advanced techniques to ensure exceptional specificity and sensitivity, enabling precise detection and analysis of Cyclin E1 protein expression.

The Cyclin E1 Polyclonal Antibody exhibits outstanding performance across a wide range of applications, including immunohistochemistry, western blotting, and immunofluorescence. Its versatility allows for seamless integration into various experimental protocols, providing researchers with unparalleled flexibility and convenience.

With its superior affinity and selectivity, this antibody guarantees minimal cross-reactivity, ensuring the utmost accuracy in target protein identification. Its robust and consistent performance ensures reproducible results, empowering researchers to confidently draw meaningful conclusions from their experiments.

Crafted with meticulous attention to detail, the Cyclin E1 Polyclonal Antibody is manufactured using state-of-the-art technology and undergoes rigorous quality control measures. This ensures batch-to-batch consistency, guaranteeing reliable and reproducible results with every use.

Furthermore, this antibody is supplied in a convenient and user-friendly format, allowing for easy storage and handling. Its long shelf life ensures prolonged usability, making it an economical choice for laboratories and research institutions.

In summary, the Cyclin E1 Polyclonal Antibody is an indispensable tool for researchers seeking to unravel the intricate mechanisms of cell cycle regulation. Its exceptional performance, reliability, and ease of use make it an invaluable asset in advancing scientific knowledge and understanding in this critical field.