Cyclin D3 Polyclonal Antibody

The protein encoded by CCND3 (cyclin D3) belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activtiy is required for cell cycle G1/S transition. This protein has been shown to interact with and be involved in the phosphorylation of tumor suppressor protein Rb. The CDK4 activity associated with this cyclin was reported to be necessary for cell cycle progression through G2 phase into mitosis after UV radiation. Several transcript variants encoding different isoforms have been found for CCND3.

The Cyclin D3 Polyclonal Antibody is a highly specific and sensitive tool designed for the detection and quantification of Cyclin D3 protein in various biological samples. This antibody has been meticulously developed using advanced techniques to ensure exceptional performance and reliability.

Cyclin D3 is a crucial regulator of the cell cycle, playing a pivotal role in cell proliferation and differentiation. Its aberrant expression has been implicated in numerous diseases, including cancer. Therefore, the accurate measurement of Cyclin D3 protein levels is of utmost importance in both research and clinical settings.

This polyclonal antibody exhibits exceptional specificity, binding exclusively to Cyclin D3 protein without cross-reactivity to other cyclin family members. It has been rigorously validated using various experimental approaches, including Western blotting, immunohistochemistry, and immunofluorescence, ensuring its suitability for a wide range of applications.

The Cyclin D3 Polyclonal Antibody demonstrates outstanding sensitivity, enabling the detection of low levels of Cyclin D3 protein with high precision. Its robust performance ensures reliable and reproducible results, making it an invaluable tool for researchers and clinicians alike.

Furthermore, this antibody has been manufactured under stringent quality control measures to ensure batch-to-batch consistency and optimal performance. It is supplied in a convenient format, allowing for easy handling and storage.

In summary, the Cyclin D3 Polyclonal Antibody is a highly specific, sensitive, and reliable tool for the detection and quantification of Cyclin D3 protein. Its exceptional performance and versatility make it an indispensable asset in various research and clinical applications, facilitating a deeper understanding of cell cycle regulation and disease pathology.