Cyclin D1 Polyclonal Antibody

Cyclin D1 encoded by CCND1 belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance throughout the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activity is required for cell cycle G1/S transition. Cyclin D1 has been shown to interact with tumor suppressor protein Rb and the expression of this gene is regulated positively by Rb. Mutations, amplification and overexpression of CCND1, which alters cell cycle progression, are observed frequently in a variety of tumors and may contribute to tumorigenesis.

The Cyclin D1 Polyclonal Antibody is a highly specific and sensitive tool designed for the detection and quantification of Cyclin D1 protein in various biological samples. This antibody is produced using advanced recombinant DNA technology, ensuring high purity and batch-to-batch consistency.

Cyclin D1 is a crucial regulator of the cell cycle, playing a pivotal role in cell proliferation and differentiation. Aberrant expression of Cyclin D1 has been implicated in numerous pathological conditions, including cancer. Therefore, accurate measurement of Cyclin D1 levels is of utmost importance in both research and clinical settings.

The Cyclin D1 Polyclonal Antibody exhibits exceptional specificity, binding exclusively to Cyclin D1 protein without cross-reactivity to other cyclin family members. This antibody has been extensively validated in various experimental models, including Western blotting, immunohistochemistry, and immunofluorescence, ensuring reliable and reproducible results.

With its high sensitivity, this antibody allows for the detection of low levels of Cyclin D1 protein, enabling researchers to study its expression dynamics in different cell types and tissues. Moreover, the Cyclin D1 Polyclonal Antibody demonstrates excellent performance in both human and animal samples, making it a versatile tool for a wide range of applications.

The Cyclin D1 Polyclonal Antibody is supplied in a convenient and ready-to-use format, ensuring ease of use and saving valuable time in the laboratory. It is available in various sizes to accommodate different experimental needs. Each batch of this antibody undergoes rigorous quality control procedures to guarantee optimal performance and consistency.

In summary, the Cyclin D1 Polyclonal Antibody is a reliable and efficient tool for the accurate detection and quantification of Cyclin D1 protein. Its exceptional specificity, sensitivity, and versatility make it an invaluable asset for researchers and clinicians studying cell cycle regulation and its implications in various diseases.