Cyclin D1 Polyclonal Antibody

The protein encoded by CCND1 (cyclin D1) belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance throughout the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activity is required for cell cycle G1/S transition. This protein has been shown to interact with tumor suppressor protein Rb and the expression of CCND1 is regulated positively by Rb. Mutations, amplification and overexpression of this gene, which alters cell cycle progression, are observed frequently in a variety of tumors and may contribute to tumorigenesis.

The CYCLIN D1 Polyclonal Antibody is a highly specific and sensitive tool designed for the detection and quantification of CYCLIN D1 protein expression in various biological samples. This antibody is produced using advanced immunization techniques, resulting in a high affinity and specificity towards CYCLIN D1.

The CYCLIN D1 Polyclonal Antibody has been extensively validated for its performance in various applications, including Western blotting, immunohistochemistry, and immunofluorescence. It exhibits exceptional sensitivity and minimal cross-reactivity, ensuring accurate and reliable results.

This antibody is supplied as a liquid formulation, allowing for easy and convenient handling. It is provided in a ready-to-use format, eliminating the need for time-consuming preparation steps. The CYCLIN D1 Polyclonal Antibody is compatible with a wide range of sample types, including cell lysates, tissue extracts, and cultured cells.

With its exceptional performance and versatility, the CYCLIN D1 Polyclonal Antibody is an indispensable tool for researchers and scientists studying cell cycle regulation, cancer biology, and related fields. Its reliable and reproducible results make it an ideal choice for both basic research and clinical applications.