CYB561D1 Polyclonal Antibody

CYB561D2 (Cytochrome b561 domain-containing protein 2), also known as putative tumor suppressor protein 101F6, is a 222 amino acid highly hydrophobic protein that contains six membrane spanning domains. Localized to endosomes and endoplasmic reticulum of the perinuclear region, CYB561D2 contains 2 heme-binding sites, through which it reduces ferric ions. CYB561D2 is ubiquitously expressed, with highest levels in lung, liver and kidney. Though expression of CYB561D2 is abundant in normal lung bronchial epithileal cells, CYB561D2 is absent in most lung cancers. The gene encoding CYB561D2 maps to human chromosome 3p21.3, a region that is prone to genetic alterations and is associated with frequent and early allele loss in many human cancers. Exogenous expression of CYB561D2 leads to the induction of caspase-independent apoptotic and autophagic pathways, resulting in the synergistic killing of tumor cells. This suggests an important role for CYB561D2 as a therapeutic intervention in cancer treatment.

The CYB561D1 Polyclonal Antibody is a highly specific and sensitive immunological reagent designed for the detection and quantification of CYB561D1 protein in various biological samples. This antibody is produced by immunizing rabbits with a synthetic peptide corresponding to a specific region of the CYB561D1 protein. The resulting polyclonal antibody exhibits high affinity and specificity towards the target protein, making it an ideal tool for various applications in research and diagnostics.

The CYB561D1 Polyclonal Antibody is suitable for use in various immunoassays, including Western blotting, immunohistochemistry, and ELISA. It has been validated for use in human, mouse, and rat samples, and has been shown to exhibit minimal cross-reactivity with other proteins. The antibody is supplied as a purified IgG fraction, and is available in various sizes to suit different experimental needs.

The CYB561D1 Polyclonal Antibody is manufactured to the highest quality standards, ensuring reproducible and reliable results. It is rigorously tested for purity, specificity, and functionality, and is guaranteed to perform as described. This antibody is an essential tool for researchers and clinicians working in the fields of neuroscience, metabolism, and cellular physiology, and is an excellent choice for anyone seeking a high-quality polyclonal antibody for the detection of CYB561D1 protein.