CUL-2 Polyclonal Antibody

Cullin proteins comprise a distinct family of mediators that participate in the selective targeting of proteins for ubiquitin (Ub)-mediated proteolysis. CUL-1, which is the mammalian homolog of yeast Cdc53, is an integral component of the E3 ubiquitin ligase complex designated SCF. The SCF (Skp1/CUL-1/F-box protein complex) consists of Skp1 associating with both CUL-1 and an F-box protein, such as Skp2, which determines the substrate specificity of the complex. CUL-1-mediated ubiquitination results in the degradation of cell cycle proteins cyclin D, p21 and cyclin E. Another cullin, CUL-3, facilitates the degradation of cyclin E independent of SCF activity, while CUL-2 associates with the tumor suppressing protein VHL and elongin B to form VBC complexes, which structurally resemble the SCF ligase. Proteolysis also occurs by way of CUL-4 associating with Nedd-8, a ubiquitin-like protein, where it too functions as an active component of a multifunctional E3 complex. CUL-5, also designated vasopressin-activated, calcium-mobilizing protein (VACM-1), is also included in the cullin family as it shares substantial sequence homology with CUL-1.

The CUL-2 Polyclonal Antibody is a highly specific and sensitive antibody designed for use in various research applications. This antibody is produced using high-quality materials and advanced techniques to ensure optimal performance and reliability. It is designed to target the CUL-2 protein, which is a key component of the Cullin-RING E3 ubiquitin ligase complex. The CUL-2 Polyclonal Antibody is suitable for use in Western blotting, immunohistochemistry, and other applications where high specificity and sensitivity are required.

It is supplied in a convenient format and is ready to use with minimal preparation. This antibody is an essential tool for researchers studying the role of CUL-2 in various cellular processes and diseases. With its exceptional performance and reliability, the CUL-2 Polyclonal Antibody is an excellent choice for any research project requiring high-quality antibodies.