Csk Polyclonal Antibody

All members of the Src gene family of tyrosine kinases are characterized by a carboxy terminal domain tyrosine which is highly phosphorylated in the inactive form of the enzyme and phosphorylated to a much lesser extent when the enzyme is active. In the case of Src p60, Y527 is this tyrosine; however, a mutant form of c-Src in which Y527 is replaced by phenylalanine is transforming and displays 5- to 10-fold elevated kinase activity compared to its normal counterpart. Csk has been identified as a Src-related tyrosine kinase having both SH2 and SH3 domains and a catalytic domain but lacking sequences amino terminal to the SH3 domain as well as carboxy terminal regulatory sequences. Csk phosphorylates Src on Y527 and also downregulates Lyn, Fyn and Lck by tyrosine phosphorylation of carboxy terminal regulatory sites.

The CSK Polyclonal Antibody is a highly specific and sensitive immunological reagent designed for the detection and quantification of the CSK protein in various biological samples. This antibody is produced by immunizing rabbits with a synthetic peptide corresponding to the C-terminal region of the human CSK protein. The resulting polyclonal antibody exhibits high affinity and specificity towards the CSK protein, making it an ideal tool for a wide range of applications in research and diagnostics.

The CSK Polyclonal Antibody is suitable for use in various immunoassays, including Western blotting, immunoprecipitation, and immunohistochemistry. It has been validated for use in human, mouse, and rat samples, and has been shown to detect endogenous levels of CSK protein in various cell lines and tissues. The antibody is supplied as a purified IgG fraction, and has been tested for its purity, specificity, and activity.

The CSK Polyclonal Antibody is a valuable tool for researchers studying the role of CSK in various cellular processes, including cell signaling, proliferation, and differentiation. It can also be used in clinical settings for the diagnosis and monitoring of diseases associated with CSK dysregulation, such as cancer and autoimmune disorders. With its high specificity and sensitivity, the CSK Polyclonal Antibody is a reliable and effective reagent for the detection and quantification of CSK protein in biological samples.