Crk-L Polyclonal Antibody

CRKL encodes a protein kinase containing SH2 and SH3 (src homology) domains which has been shown to activate the RAS and JUN kinase signaling pathways and transform fibroblasts in a RAS-dependent fashion. It is a substrate of the BCR-ABL tyrosine kinase, plays a role in fibroblast transformation by BCR-ABL, and may be oncogenic.

The CRK-L polyclonal antibody is a highly specific and sensitive immunological reagent designed for the detection and quantification of CRK-L protein in various biological samples. This antibody is produced by immunizing rabbits with a synthetic peptide corresponding to the C-terminal region of human CRK-L protein. The resulting polyclonal antibody exhibits high affinity and specificity towards CRK-L protein, making it an ideal tool for various applications in research and diagnostics.

The CRK-L polyclonal antibody is suitable for use in various immunoassays, including Western blotting, immunohistochemistry, and ELISA. It has been validated for use in human, mouse, and rat samples, and has been shown to detect endogenous levels of CRK-L protein in various tissues and cell lines. The antibody is supplied as a purified IgG fraction, and has been tested for purity, specificity, and functionality to ensure consistent and reliable results.

In summary, the CRK-L polyclonal antibody is a high-quality immunological reagent that offers exceptional sensitivity and specificity for the detection and quantification of CRK-L protein in various biological samples. Its versatility and reliability make it an essential tool for researchers and clinicians working in the fields of cancer biology, signal transduction, and cell biology.