Crk II Polyclonal Antibody

CRK encodes a member of an adapter protein family that binds to several tyrosine-phosphorylated proteins. The product of CRK has several SH2 and SH3 domains (src-homology domains) and is involved in several signaling pathways, recruiting cytoplasmic proteins in the vicinity of tyrosine kinase through SH2-phosphotyrosine interaction. The N-terminal SH2 domain of this protein functions as a positive regulator of transformation whereas the C-terminal SH3 domain functions as a negative regulator of transformation. Two alternative transcripts encoding different isoforms with distinct biological activity have been described.

The CRK II Polyclonal Antibody is a highly specific and sensitive immunological reagent designed for the detection and quantification of CRK II protein in various biological samples. This antibody is produced by immunizing rabbits with a synthetic peptide corresponding to the C-terminal region of human CRK II protein. The resulting polyclonal antibody exhibits high affinity and specificity towards CRK II protein, making it an ideal tool for various applications in research and diagnostics.

The CRK II Polyclonal Antibody is suitable for use in Western blotting, immunoprecipitation, immunohistochemistry, and other immunoassays. It has been validated for use in human, mouse, and rat samples, and has been shown to detect endogenous levels of CRK II protein in various tissues and cell lines. This antibody is supplied as a purified IgG fraction, and has been tested for its purity, specificity, and activity.

The CRK II Polyclonal Antibody is a valuable tool for researchers studying the role of CRK II protein in various cellular processes, including cell adhesion, migration, and proliferation. It can also be used for the diagnosis and prognosis of various diseases, including cancer, where CRK II protein has been implicated in tumor growth and metastasis. With its high specificity and sensitivity, the CRK II Polyclonal Antibody is a reliable and effective reagent for the detection and quantification of CRK II protein in biological samples.