c-Rel Polyclonal Antibody

REL (REL proto-oncogene, NF-kB subunit) encodes a protein that belongs to the Rel homology domain/immunoglobulin-like fold, plexin, transcription factor (RHD/IPT) family. Members of this family regulate genes involved in apoptosis, inflammation, the immune response, and oncogenic processes. This proto-oncogene plays a role in the survival and proliferation of B lymphocytes. Mutation or amplification of REL is associated with B-cell lymphomas, including Hodgkin's lymphoma. Single nucleotide polymorphisms in REL are associated with susceptibility to ulcerative colitis and rheumatoid arthritis. Alternative splicing results in multiple transcript variants encoding different isoforms.

The c-Rel Polyclonal Antibody is a highly specific and sensitive antibody that has been designed for use in various research applications. This antibody is produced by immunizing rabbits with a synthetic peptide corresponding to the C-terminal region of human c-Rel protein. The resulting polyclonal antibody has been purified using protein A affinity chromatography and is suitable for use in Western blotting, immunohistochemistry, and immunofluorescence assays.

The c-Rel Polyclonal Antibody has been extensively validated for its specificity and sensitivity in detecting c-Rel protein in various cell types and tissues. It has been shown to recognize both the full-length and truncated forms of c-Rel protein, making it a versatile tool for studying the function and regulation of this important transcription factor.

This antibody is supplied as a liquid in phosphate-buffered saline (PBS) containing 0.02% sodium azide as a preservative. It is recommended to store the antibody at -20°C for long-term storage and to avoid repeated freeze-thaw cycles.

In summary, the c-Rel Polyclonal Antibody is a reliable and high-quality reagent that can be used for a wide range of research applications. Its specificity and sensitivity make it an ideal tool for studying the role of c-Rel in various biological processes.