COX11 Polyclonal Antibody

Cytochrome c oxidase (COX), the terminal component of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. This component is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in electron transfer, and the nuclear-encoded subunits may function in the regulation and assembly of the complex. COX11 encodes COX11, cytochrome c oxidase copper chaperone which is not a structural subunit, but may be a heme A biosynthetic enzyme involved in COX formation, according to the yeast mutant studies. However, the studies in Rhodobacter sphaeroides suggest that this gene is not required for heme A biosynthesis, but required for stable formation of the Cu(B) and magnesium centers of COX. This human protein is predicted to contain a transmembrane domain localized in the mitochondrial inner membrane. Multiple transcript variants encoding different isoforms have been found for this gene. A related pseudogene has been found on chromosome 6.

The COX11 Polyclonal Antibody is a highly specific and sensitive antibody designed for the detection of COX11 protein in various biological samples. This antibody is produced by immunizing rabbits with a synthetic peptide corresponding to the C-terminal region of human COX11 protein. The resulting polyclonal antibody has been purified using protein A affinity chromatography and validated for its specificity and sensitivity through various assays.

The COX11 protein is a mitochondrial protein that plays a crucial role in the assembly of cytochrome c oxidase, a key enzyme in the electron transport chain. Dysregulation of COX11 expression has been implicated in various diseases, including cancer and neurodegenerative disorders. Therefore, the COX11 Polyclonal Antibody is an essential tool for researchers studying the role of COX11 in these diseases.

This antibody is suitable for use in various applications, including Western blotting, immunohistochemistry, and immunofluorescence. It has been validated for its specificity and sensitivity in detecting COX11 protein in human, mouse, and rat samples. The COX11 Polyclonal Antibody is supplied as a liquid in phosphate-buffered saline (PBS) with 0.02% sodium azide as a preservative.

In summary, the COX11 Polyclonal Antibody is a highly specific and sensitive antibody that is essential for researchers studying the role of COX11 in various diseases. Its validated specificity and sensitivity make it a reliable tool for detecting COX11 protein in various biological samples.