COX10 Polyclonal Antibody

Cytochrome c oxidase (COX), the terminal component of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. This component is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in electron transfer, and the nuclear-encoded subunits may function in the regulation and assembly of the complex. COX10 encodes heme A:  farnesyltransferase, which is not a structural subunit but required for the expression of functional COX and functions in the maturation of the heme A prosthetic group of COX. COX10, heme A:  farnesyltransferase cytochrome c oxidase assembly factor is predicted to contain 7-9 transmembrane domains localized in the mitochondrial inner membrane. A gene mutation, which results in the substitution of a lysine for an asparagine (N204K), is identified to be responsible for cytochrome c oxidase deficiency. In addition, this gene is disrupted in patients with CMT1A (Charcot-Marie-Tooth type 1A) duplication and with HNPP (hereditary neuropathy with liability to pressure palsies) deletion.

The COX10 Polyclonal Antibody is a highly specific and reliable tool designed for the detection and analysis of COX10 protein expression in various biological samples. This antibody has been extensively validated for its superior performance in immunohistochemistry (IHC), immunofluorescence (IF), and western blotting (WB) applications.

COX10, also known as cytochrome c oxidase assembly factor 10, plays a crucial role in the assembly of cytochrome c oxidase (COX), a key enzyme complex involved in the electron transport chain of mitochondria. Dysregulation of COX10 has been implicated in various mitochondrial disorders and diseases, making it an important target for research and diagnostic purposes.

The COX10 Polyclonal Antibody has been produced using high-quality immunogens and advanced immunization techniques, ensuring its specificity and sensitivity towards COX10 protein. It exhibits minimal cross-reactivity with other related proteins, ensuring accurate and reliable results.

This antibody offers exceptional versatility, enabling its use in a wide range of experimental techniques. In IHC, it enables precise localization and visualization of COX10 protein expression in tissue sections, allowing for detailed analysis of its distribution and cellular localization. In IF, it facilitates the detection of COX10 in fixed cells, enabling the investigation of its subcellular localization and co-localization with other cellular markers. In WB, it enables the detection and quantification of COX10 protein levels in cell lysates, providing valuable insights into its expression and regulation.

The COX10 Polyclonal Antibody is supplied as a ready-to-use solution, ensuring convenience and ease of use. It has been rigorously tested and validated to ensure consistent and reproducible results. Each batch is accompanied by a detailed datasheet, providing comprehensive information on its recommended working conditions and protocols.

In summary, the COX10 Polyclonal Antibody is a highly reliable and specific tool for the detection and analysis of COX10 protein expression. Its exceptional performance in IHC, IF, and WB applications, along with its versatility and convenience, make it an ideal choice for researchers and clinicians involved in mitochondrial research, disease diagnostics, and therapeutic development.