Cortactin (Acetyl Lys235) Polyclonal Antibody

CTTN is overexpressed in breast cancer and squamous cell carcinomas of the head and neck. Cortactin is localized in the cytoplasm and in areas of the cell-substratum contacts. This gene has two roles: (1) regulating the interactions between components of adherens-type junctions and (2) organizing the cytoskeleton and cell adhesion structures of epithelia and carcinoma cells. During apoptosis, cortactin is degraded in a caspase-dependent manner. The aberrant regulation of CTTN contributes to tumor cell invasion and metastasis. Three splice variants that encode different isoforms have been identified for CTTN.

The Cortactin (Acetyl Lys235) Polyclonal Antibody is a highly specific and sensitive immunological reagent designed for the detection and quantification of Cortactin protein in various biological samples. This antibody is produced by immunizing rabbits with a synthetic peptide corresponding to the acetylated Lys235 region of human Cortactin protein. The resulting polyclonal antibody exhibits high affinity and specificity towards the acetylated Lys235 residue of Cortactin protein, making it an ideal tool for studying the post-translational modifications of Cortactin protein.

The Cortactin (Acetyl Lys235) Polyclonal Antibody is suitable for use in various applications, including Western blotting, immunoprecipitation, and immunofluorescence. It has been validated for use in human, mouse, and rat samples, and has been shown to detect endogenous levels of Cortactin protein in various cell lines and tissues. This antibody is supplied as a purified IgG fraction, and has been tested for its specificity and sensitivity in various experimental conditions.

Overall, the Cortactin (Acetyl Lys235) Polyclonal Antibody is a reliable and high-quality reagent that can be used for the detection and quantification of Cortactin protein in various biological samples. Its high specificity and sensitivity make it an ideal tool for studying the post-translational modifications of Cortactin protein, and its versatility makes it suitable for use in a wide range of applications.