COL6A1 Polyclonal Antibody

The collagens are a superfamily of proteins that play a role in maintaining the integrity of various tissues. Collagens are extracellular matrix proteins and have a triple-helical domain as their common structural element. Collagen VI is a major structural component of microfibrils. The basic structural unit of collagen VI is a heterotrimer of the alpha1(VI), alpha2(VI), and alpha3(VI) chains. The alpha2(VI) and alpha3(VI) chains are encoded by the COL6A2 and COL6A3 genes, respectively. The collagen type VI alpha 1 chain encoded by COL6A1 is the alpha 1 subunit of type VI collagen (alpha1(VI) chain). Mutations in the genes that code for the collagen VI subunits result in the autosomal dominant disorder, Bethlem myopathy.

The COL6A1 Polyclonal Antibody is a highly specific and sensitive antibody designed for the detection of COL6A1 protein in various biological samples. This antibody is produced by immunizing rabbits with a synthetic peptide corresponding to the N-terminal region of human COL6A1 protein. The antibody has been purified using protein A affinity chromatography and is supplied as a liquid formulation in phosphate-buffered saline (PBS) with 0.02% sodium azide as a preservative.

The COL6A1 Polyclonal Antibody has been extensively validated for its specificity and sensitivity in various applications, including Western blotting, immunohistochemistry, and immunofluorescence. It has been shown to specifically recognize the COL6A1 protein in human, mouse, and rat tissues, making it a versatile tool for researchers studying the role of COL6A1 in various biological processes.

This antibody is suitable for use in both basic research and clinical applications, including the diagnosis and prognosis of diseases associated with COL6A1 expression. It is recommended for use at a dilution of 1:1000 for Western blotting and 1:200 for immunohistochemistry and immunofluorescence.

In summary, the COL6A1 Polyclonal Antibody is a reliable and high-quality tool for the detection of COL6A1 protein in various biological samples. Its specificity and sensitivity make it an ideal choice for researchers and clinicians studying the role of COL6A1 in health and disease.