COL4A3 Polyclonal Antibody

Type IV collagen, the major structural component of basement membranes, is a multimeric protein composed of 3 alpha subunits. These subunits are encoded by 6 different genes, alpha 1 through alpha 6, each of which can form a triple helix structure with 2 other subunits to form type IV collagen. COL4A3 encodes alpha 3. In the Goodpasture syndrome, autoantibodies bind to the collagen molecules in the basement membranes of alveoli and glomeruli. The epitopes that elicit these autoantibodies are localized largely to the non-collagenous C-terminal domain of the protein. A specific kinase phosphorylates amino acids in this same C-terminal region and the expression of this kinase is upregulated during pathogenesis. COL4A3 is also linked to an autosomal recessive form of Alport syndrome. The mutations contributing to this syndrome are also located within the exons that encode this C-terminal region. Like the other members of the type IV collagen gene family, COL4A3 is organized in a head-to-head conformation with another type IV collagen gene so that each gene pair shares a common promoter.

The COL4A3 Polyclonal Antibody is a highly specific and sensitive tool designed for the detection and analysis of COL4A3 protein expression. This antibody is produced through a rigorous process, ensuring its high quality and reliability. It has been extensively validated for various applications, including Western blotting, immunohistochemistry, and immunofluorescence.

The COL4A3 Polyclonal Antibody exhibits exceptional specificity, binding exclusively to the COL4A3 protein without cross-reactivity to other related proteins. Its high sensitivity allows for the detection of even low levels of COL4A3 expression, enabling accurate quantification and analysis.

This antibody is suitable for a wide range of research applications, including studies on extracellular matrix remodeling, basement membrane structure, and renal diseases. Its versatility and robust performance make it an indispensable tool for researchers in the fields of molecular biology, biochemistry, and pathology.

The COL4A3 Polyclonal Antibody is supplied in a convenient and ready-to-use format, ensuring ease of use and saving valuable time in the laboratory. It is available in various sizes to accommodate different experimental needs.

With its exceptional specificity, sensitivity, and versatility, the COL4A3 Polyclonal Antibody is an essential tool for researchers seeking to unravel the complexities of COL4A3 protein expression and its implications in various biological processes and diseases.