COL18A1 Polyclonal Antibody

COL18A1 (collagen type XVIII alpha 1 chain) encodes the alpha chain of type XVIII collagen. This collagen is one of the multiplexins, extracellular matrix proteins that contain multiple triple-helix domains (collagenous domains) interrupted by non-collagenous domains. A long isoform of the protein has an N-terminal domain that is homologous to the extracellular part of frizzled receptors. Proteolytic processing at several endogenous cleavage sites in the C-terminal domain results in production of endostatin, a potent antiangiogenic protein that is able to inhibit angiogenesis and tumor growth. Mutations in COL18A1 are associated with Knobloch syndrome. The main features of this syndrome involve retinal abnormalities, so type XVIII collagen may play an important role in retinal structure and in neural tube closure. Alternative splicing results in multiple transcript variants.

The COL18A1 polyclonal antibody is a meticulously crafted product designed to cater to the needs of researchers and scientists in the field of molecular biology. This antibody, derived from a diverse pool of immunized animals, exhibits exceptional specificity and sensitivity, making it an invaluable tool for the detection and analysis of COL18A1 protein expression.

With its high affinity and selectivity, this polyclonal antibody enables accurate identification and quantification of COL18A1 in various biological samples. Its robust performance ensures reliable and reproducible results, facilitating comprehensive investigations into the role and function of COL18A1 in physiological and pathological processes.

The COL18A1 polyclonal antibody is meticulously manufactured using state-of-the-art techniques, ensuring optimal quality and consistency. Rigorous quality control measures are implemented throughout the production process to guarantee batch-to-batch reproducibility and reliability. This antibody is validated for various applications, including Western blotting, immunohistochemistry, and immunofluorescence, providing researchers with versatile options for their experimental needs.

Furthermore, this polyclonal antibody is supplied in a convenient and user-friendly format, allowing for easy handling and storage. Its long shelf life ensures prolonged usability, minimizing the need for frequent reordering and ensuring cost-effectiveness for laboratories and research institutions.

In summary, the COL18A1 polyclonal antibody is an indispensable tool for researchers seeking to unravel the intricacies of COL18A1 protein expression. Its exceptional specificity, sensitivity, and reliability make it an ideal choice for a wide range of applications, enabling groundbreaking discoveries and advancements in the field of molecular biology.