COL17A1 Polyclonal Antibody

COL17A1 encodes the alpha chain of type XVII collagen. Unlike most collagens, collagen XVII is a transmembrane protein. Collagen XVII is a structural component of hemidesmosomes, multiprotein complexes at the dermal-epidermal basement membrane zone that mediate adhesion of keratinocytes to the underlying membrane. Mutations in this gene are associated with both generalized atrophic benign and junctional epidermolysis bullosa. Two homotrimeric forms of type XVII collagen exist. The full length form is the transmembrane protein. A soluble form, referred to as either ectodomain or LAD-1, is generated by proteolytic processing of the full length form.

The COL17A1 Polyclonal Antibody is a highly specific and reliable tool designed for the detection and analysis of COL17A1 protein expression in various biological samples. This antibody is produced through a rigorous process, ensuring its high affinity and specificity towards the target protein.

COL17A1, also known as collagen type XVII alpha 1 chain, is a transmembrane protein that plays a crucial role in maintaining the integrity of epithelial tissues. It is primarily expressed in the basal cells of stratified epithelia and is involved in cell adhesion and migration processes. Dysregulation of COL17A1 has been implicated in various pathological conditions, including autoimmune blistering diseases and cancer progression.

The COL17A1 Polyclonal Antibody exhibits exceptional sensitivity and specificity, making it an ideal choice for a wide range of applications, including Western blotting, immunohistochemistry, and immunofluorescence. It has been extensively validated in multiple experimental settings, ensuring accurate and reproducible results.

This antibody is supplied as a liquid formulation, allowing for easy handling and convenient storage. It is provided in a ready-to-use format, eliminating the need for time-consuming preparation steps. The COL17A1 Polyclonal Antibody is compatible with various detection systems and can be used in combination with other antibodies for multiplex analysis.

With its superior performance and reliability, the COL17A1 Polyclonal Antibody is an indispensable tool for researchers and clinicians studying the role of COL17A1 in various biological processes and diseases. Its high specificity and sensitivity make it an invaluable asset in advancing our understanding of epithelial tissue biology and developing potential therapeutic interventions.