c-Myc Polyclonal Antibody

V-myc avian myelocytomatosis viral oncogene homolog encoded by MYC is a multifunctional, nuclear phosphoprotein that plays a role in cell cycle progression, apoptosis and cellular transformation. It functions as a transcription factor that regulates transcription of specific target genes. Mutations, overexpression, rearrangement and translocation of this gene have been associated with a variety of hematopoietic tumors, leukemias and lymphomas, including Burkitt lymphoma. There is evidence to show that alternative translation initiations from an upstream, in-frame non-AUG (CUG) and a downstream AUG start site result in the production of two isoforms with distinct N-termini. The synthesis of non-AUG initiated protein is suppressed in Burkitt's lymphomas, suggesting its importance in the normal function of MYC.

The c-Myc Polyclonal Antibody is a highly specific and sensitive antibody designed for the detection of c-Myc protein in various biological samples. This antibody is produced by immunizing rabbits with a synthetic peptide corresponding to the N-terminal region of human c-Myc protein. The antibody has been purified using protein A affinity chromatography and is supplied as a liquid formulation in phosphate-buffered saline (PBS) with 0.02% sodium azide as a preservative.

The c-Myc Polyclonal Antibody has been extensively validated for use in various applications, including Western blotting, immunohistochemistry, and immunofluorescence. It has been shown to specifically recognize c-Myc protein in a variety of cell lines and tissues, including human, mouse, and rat. The antibody has also been shown to be highly sensitive, with a detection limit of 0.1 ng of c-Myc protein.

This antibody is an essential tool for researchers studying the role of c-Myc in various biological processes, including cell proliferation, differentiation, and apoptosis. It can also be used for diagnostic purposes, such as the detection of c-Myc overexpression in cancer cells. The c-Myc Polyclonal Antibody is a reliable and high-quality reagent that is backed by our rigorous quality control standards and our commitment to customer satisfaction.