Cleaved-Tumstatin (P1426) Polyclonal Antibody

Type IV collagen, the major structural component of basement membranes, is a multimeric protein composed of 3 alpha subunits. These subunits are encoded by 6 different genes, alpha 1 through alpha 6, each of which can form a triple helix structure with 2 other subunits to form type IV collagen. COL4A3 encodes alpha 3. In the Goodpasture syndrome, autoantibodies bind to the collagen molecules in the basement membranes of alveoli and glomeruli. The epitopes that elicit these autoantibodies are localized largely to the non-collagenous C-terminal domain of the protein. A specific kinase phosphorylates amino acids in this same C-terminal region and the expression of this kinase is upregulated during pathogenesis. COL4A3 is also linked to an autosomal recessive form of Alport syndrome. The mutations contributing to this syndrome are also located within the exons that encode this C-terminal region. Like the other members of the type IV collagen gene family, COL4A3 is organized in a head-to-head conformation with another type IV collagen gene so that each gene pair shares a common promoter.

Introducing the Cleaved-Tumstatin (P1426) Polyclonal Antibody, a cutting-edge immunological tool meticulously designed to facilitate advanced research in the field of cancer biology. This highly specific antibody is engineered to recognize and bind to the cleaved form of Tumstatin (P1426), a crucial protein fragment implicated in tumor angiogenesis and metastasis.

Crafted with utmost precision, this polyclonal antibody exhibits exceptional affinity and selectivity towards the cleaved-Tumstatin (P1426) epitope, enabling accurate detection and quantification of this critical biomarker. Its robust performance is attributed to the rigorous purification process, ensuring minimal cross-reactivity and maximum signal-to-noise ratio, thereby guaranteeing reliable and reproducible results.

The Cleaved-Tumstatin (P1426) Polyclonal Antibody is meticulously validated through various experimental techniques, including Western blotting, immunohistochemistry, and immunofluorescence, to ascertain its efficacy across diverse applications. Its versatility extends to multiple species, making it an invaluable asset for researchers working with human, mouse, and rat samples.

This antibody is supplied in a convenient and user-friendly format, facilitating seamless integration into existing laboratory protocols. With its exceptional sensitivity and specificity, it empowers researchers to unravel the intricate mechanisms underlying tumor angiogenesis and metastasis, paving the way for novel therapeutic interventions and prognostic markers.

Choose the Cleaved-Tumstatin (P1426) Polyclonal Antibody to unlock the potential of your cancer research endeavors. Experience unparalleled accuracy, reliability, and reproducibility, as you delve deeper into the intricate complexities of tumorigenesis. Trust in this cutting-edge immunological tool to revolutionize your scientific pursuits and contribute to the advancement of cancer biology.