Cleaved-TACE (R215) Polyclonal Antibody

ADAM17 (ADAM metallopeptidase domain 17) encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biologic processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. The encoded preproprotein is proteolytically processed to generate the mature protease. The encoded protease functions in the ectodomain shedding of tumor necrosis factor-alpha, in which soluble tumor necrosis factor-alpha is released from the membrane-bound precursor. This protease also functions in the processing of numerous other substrates, including cell adhesion proteins, cytokine and growth factor receptors and epidermal growth factor (EGF) receptor ligands. The encoded protein also plays a prominent role in the activation of the Notch signaling pathway. Elevated expression of ADAM17 has been observed in specific cell types derived from psoriasis, rheumatoid arthritis, multiple sclerosis and Crohn's disease patients, suggesting that the encoded protein may play a role in autoimmune disease.

The CLN1 Polyclonal Antibody is a highly specific and sensitive immunological reagent designed for the detection and quantification of CLN1 protein in various biological samples. This antibody is produced by immunizing rabbits with a synthetic peptide corresponding to the N-terminal region of human CLN1 protein. The resulting polyclonal antibody exhibits high affinity and specificity towards CLN1 protein, making it an ideal tool for various research applications.

The CLN1 Polyclonal Antibody is suitable for use in a variety of immunoassays, including Western blotting, immunohistochemistry, and ELISA. It has been validated for use in human, mouse, and rat samples, and has been shown to detect CLN1 protein in a variety of tissues and cell types. This antibody is supplied as a purified IgG fraction, and has been tested for purity and specificity by SDS-PAGE and immunoblotting.

The CLN1 Polyclonal Antibody is a valuable tool for researchers studying the role of CLN1 protein in various biological processes, including lysosomal storage disorders and neurodegenerative diseases. Its high sensitivity and specificity make it an ideal reagent for the detection and quantification of CLN1 protein in complex biological samples. With its reliable performance and consistent results, the CLN1 Polyclonal Antibody is a trusted choice for researchers in the field of molecular biology and biochemistry.