Cleaved-Plasma Kallikrein HC (R390) Polyclonal Antibody

KLKB1 encodes a glycoprotein that participates in the surface-dependent activation of blood coagulation, fibrinolysis, kinin generation and inflammation. The encoded preproprotein present in plasma as a non-covalent complex with high molecular weight kininogen undergoes proteolytic processing mediated by activated coagulation factor XII to generate a disulfide-linked, heterodimeric serine protease comprised of heavy and light chains.

Certain mutations in KLKB1 cause prekallikrein deficiency. Alternative splicing results in multiple transcript variants encoding different isoforms.

The Cleaved-Plasma Kallikrein HC (R390) Polyclonal Antibody is a highly specific and sensitive immunological tool designed for the detection and quantification of cleaved-plasma kallikrein HC (R390) in various biological samples.

This antibody is produced by immunizing rabbits with a synthetic peptide corresponding to the C-terminal region of cleaved-plasma kallikrein HC (R390) and purified using protein A affinity chromatography. The antibody has been extensively validated for its specificity and sensitivity in various immunoassays, including Western blotting, ELISA, and immunohistochemistry. It exhibits minimal cross-reactivity with other related proteins, ensuring accurate and reliable results.

This antibody is suitable for use in research applications related to the study of plasma kallikrein HC (R390) in various physiological and pathological conditions. Its high quality and performance make it an essential tool for researchers in the fields of immunology, biochemistry, and molecular biology.