Cleaved-MMP-17 (Q129) Polyclonal Antibody

MMP17 encodes a member of the peptidase M10 family and membrane-type subfamily of matrix metalloproteinases (MMPs). Proteins in this family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Members of this subfamily contain a transmembrane domain suggesting that these proteins are expressed at the cell surface rather than secreted. The encoded preproprotein is proteolytically processed to generate the mature protease. Matrix metallopeptidase 17 is unique among the membrane-type matrix metalloproteinases in that it is anchored to the cell membrane via a glycosylphosphatidylinositol (GPI) anchor. Elevated expression of matrix metallopeptidase 17 protein has been observed in osteoarthritis and multiple human cancers.

The Cleaved-Caspase-6 p18 (D179) Polyclonal Antibody is a highly specific and sensitive tool designed for the detection and quantification of cleaved caspase-6 p18 protein in various biological samples. This antibody has been meticulously developed using advanced immunization techniques and exhibits exceptional affinity and selectivity towards the target protein.

Caspase-6 is a crucial enzyme involved in the execution phase of apoptosis, playing a pivotal role in cellular homeostasis and tissue development. The cleaved form of caspase-6, known as p18, is a reliable marker for the activation of caspase-6 and is widely used in research studies to investigate apoptotic pathways and cellular death mechanisms.

The Cleaved-Caspase-6 p18 (D179) Polyclonal Antibody demonstrates outstanding performance in various applications, including Western blotting, immunohistochemistry, and immunofluorescence. It exhibits minimal cross-reactivity with other caspase family members, ensuring accurate and specific detection of cleaved caspase-6 p18.

This antibody is produced using high-quality materials and undergoes rigorous quality control procedures to ensure batch-to-batch consistency and reproducibility. It is supplied as a liquid formulation, ready for immediate use, and is compatible with a wide range of experimental conditions and protocols.

Researchers and scientists can rely on the Cleaved-Caspase-6 p18 (D179) Polyclonal Antibody to provide reliable and precise results in their studies related to apoptosis, cellular death, and caspase-6 activation. Its exceptional sensitivity and specificity make it an indispensable tool for elucidating the intricate mechanisms underlying these processes.

Please note that this product is for research use only and is not intended for diagnostic or therapeutic purposes.