Cleaved-MMP-15 (Y132) Polyclonal Antibody

MMP15 encodes a member of the peptidase M10 family and membrane-type subfamily of matrix metalloproteinases (MMPs). Proteins in this family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Members of this subfamily contain a transmembrane domain suggesting that these proteins are expressed at the cell surface rather than secreted. The encoded preproprotein is proteolytically processed to generate the mature protease. Matrix metallopeptidase 15 may play a role in cancer progression.

The Cleaved-MMP-15 (Y132) Polyclonal Antibody is a highly specific and sensitive tool designed for the detection and quantification of cleaved matrix metalloproteinase-15 (MMP-15) in various biological samples. This antibody has been meticulously developed using advanced techniques to ensure exceptional performance and reliability.

Matrix metalloproteinases (MMPs) play a crucial role in the degradation and remodeling of extracellular matrix components, thereby influencing various physiological and pathological processes. MMP-15, also known as membrane-type 1 matrix metalloproteinase (MT1-MMP), is a key member of the MMP family involved in tissue remodeling, cell migration, and invasion.

The Cleaved-MMP-15 (Y132) Polyclonal Antibody specifically recognizes the cleaved form of MMP-15 at tyrosine 132, which is a critical site for its activation and regulation. This antibody exhibits high affinity and selectivity towards the cleaved form of MMP-15, enabling accurate detection and quantification of its activity.

This antibody has been extensively validated for its specificity and sensitivity through various experimental approaches, including Western blotting, immunohistochemistry, and immunofluorescence. It demonstrates minimal cross-reactivity with other MMP family members, ensuring reliable and precise results.

The Cleaved-MMP-15 (Y132) Polyclonal Antibody is supplied as a purified and lyophilized form, ensuring long-term stability and ease of use. It can be reconstituted in a suitable buffer for immediate application in various research areas, including cancer biology, tissue remodeling, and cell migration studies.

In summary, the Cleaved-MMP-15 (Y132) Polyclonal Antibody is a highly specific and sensitive tool that enables accurate detection and quantification of cleaved MMP-15 in biological samples. Its exceptional performance, reliability, and extensive validation make it an ideal choice for researchers aiming to investigate the role of MMP-15 in various physiological and pathological processes.