Cleaved-MASP-1 HC (R448) Polyclonal Antibody

MASP1 encodes a serine protease that functions as a component of the lectin pathway of complement activation. The complement pathway plays an essential role in the innate and adaptive immune response. The encoded protein (mannan binding lectin serine peptidase 1) is synthesized as a zymogen and is activated when it complexes with the pathogen recognition molecules of lectin pathway, the mannose-binding lectin and the ficolins. Mannan binding lectin serine peptidase 1 is not directly involved in complement activation but may play a role as an amplifier of complement activation by cleaving complement C2 or by activating another complement serine protease, MASP-2. Mannan binding lectin serine peptidase 1 is also able to cleave fibrinogen and factor XIII and may may be involved in coagulation. A splice variant of this gene which lacks the serine protease domain functions as an inhibitor of the complement pathway. Alternate splicing results in multiple transcript variants.

The Cleaved-MASP-1 HC (R448) Polyclonal Antibody is a highly specific and sensitive immunological reagent designed for the detection and quantification of Cleaved-MASP-1 HC (R448) protein in various biological samples. This antibody is produced by immunizing rabbits with a synthetic peptide corresponding to the C-terminal region of Cleaved-MASP-1 HC (R448) protein. The resulting polyclonal antibody exhibits high affinity and specificity towards the target protein, making it an ideal tool for various research applications.

The Cleaved-MASP-1 HC (R448) Polyclonal Antibody is suitable for use in various immunoassays, including Western blotting, immunohistochemistry, and ELISA. It has been validated for use in human, mouse, and rat samples, and has been shown to exhibit minimal cross-reactivity with other related proteins. This antibody is supplied as a liquid formulation, and can be stored at -20°C for long-term use.

In summary, the Cleaved-MASP-1 HC (R448) Polyclonal Antibody is a reliable and high-quality reagent that can be used for the detection and quantification of Cleaved-MASP-1 HC (R448) protein in various biological samples. Its high specificity and sensitivity make it an ideal tool for researchers studying the role of this protein in various physiological and pathological processes.