Cleaved-Integrin  AlphaV HC (K889) Polyclonal Antibody

The product of ITGAV belongs to the integrin alpha chain family. Integrins are heterodimeric integral membrane proteins composed of an alpha subunit and a beta subunit that function in cell surface adhesion and signaling. The encoded preproprotein is proteolytically processed to generate light and heavy chains that comprise the alpha V subunit. This subunit associates with beta 1, beta 3, beta 5, beta 6 and beta 8 subunits.

The heterodimer consisting of alpha V and beta 3 subunits is also known as the vitronectin receptor. This integrin may regulate angiogenesis and cancer progression. Alternative splicing results in multiple transcript variants. Note that the integrin alpha 5 and integrin alpha V subunits are encoded by distinct genes.

The Cleaved-Integrin AlphaV HC (K889) Polyclonal Antibody is a highly specific and sensitive immunological reagent designed for the detection and quantification of cleaved-integrin alphaV HC (K889) in various biological samples.

This antibody is produced by immunizing rabbits with a synthetic peptide corresponding to the cleaved-integrin alphaV HC (K889) sequence and purified using protein A affinity chromatography. The Cleaved-Integrin AlphaV HC (K889) Polyclonal Antibody has been extensively validated for its specificity and sensitivity in various applications, including Western blotting, immunohistochemistry, and ELISA.

This antibody is suitable for use in both research and diagnostic applications and is an essential tool for investigating the role of cleaved-integrin alphaV HC (K889) in various physiological and pathological processes. With its high quality and reliability, the Cleaved-Integrin AlphaV HC (K889) Polyclonal Antibody is an indispensable reagent for researchers and clinicians alike.