Cleaved-Factor XII HC (I20) Polyclonal Antibody

F12 encodes coagulation factor XII which circulates in blood as a zymogen. This single chain zymogen is converted to a two-chain serine protease with an heavy chain (alpha-factor XIIa) and a light chain. The heavy chain contains two fibronectin-type domains, two epidermal growth factor (EGF)-like domains, a kringle domain and a proline-rich domain, whereas the light chain contains only a catalytic domain. On activation, further cleavages takes place in the heavy chain, resulting in the production of beta-factor XIIa light chain and the alpha-factor XIIa light chain becomes beta-factor XIIa heavy chain. Prekallikrein is cleaved by factor XII to form kallikrein, which then cleaves factor XII first to alpha-factor XIIa and then to beta-factor XIIa. The active factor XIIa participates in the initiation of blood coagulation, fibrinolysis, and the generation of bradykinin and angiotensin. It activates coagulation factors VII and XI. Defects in this gene do not cause any clinical symptoms and the sole effect is that whole-blood clotting time is prolonged.

Introducing the Cleaved-Factor XII HC (I20) Polyclonal Antibody, a cutting-edge immunological tool designed to facilitate accurate detection and analysis of cleaved-factor XII HC. This meticulously crafted antibody is meticulously developed to ensure optimal specificity and sensitivity, enabling researchers to delve into the intricate mechanisms underlying factor XII HC cleavage.

The Cleaved-Factor XII HC (I20) Polyclonal Antibody boasts exceptional affinity towards its target, guaranteeing reliable and reproducible results. Its polyclonal nature allows for enhanced recognition of multiple epitopes, further enhancing its versatility in various experimental settings. This antibody is meticulously purified to eliminate any potential cross-reactivity, ensuring unparalleled specificity and minimizing background noise.

With its robust performance, the Cleaved-Factor XII HC (I20) Polyclonal Antibody is an invaluable asset in elucidating the role of factor XII HC cleavage in physiological and pathological processes. Its application extends to a wide range of research areas, including coagulation disorders, thrombosis, and inflammation. Researchers can confidently employ this antibody in immunohistochemistry, western blotting, and other immunological techniques to unravel the intricate intricacies of factor XII HC cleavage.

The Cleaved-Factor XII HC (I20) Polyclonal Antibody is meticulously manufactured in compliance with stringent quality control measures, ensuring batch-to-batch consistency and reliability. Its long shelf life and stability guarantee prolonged usability, making it an indispensable tool for long-term research projects.

In summary, the Cleaved-Factor XII HC (I20) Polyclonal Antibody represents a breakthrough in immunological research, offering unparalleled specificity, sensitivity, and versatility. With its exceptional performance and meticulous manufacturing, this antibody is poised to revolutionize the study of factor XII HC cleavage, empowering researchers to unravel the complexities of this crucial biological process.