Cleaved-Factor X/ Factor X LC (A41) Polyclonal Antibody

F10 encodes the vitamin K-dependent coagulation factor X of the blood coagulation cascade. This factor undergoes multiple processing steps before its preproprotein is converted to a mature two-chain form by the excision of the tripeptide RKR. Two chains of the factor are held together by 1 or more disulfide bonds; the light chain contains 2 EGF-like domains, while the heavy chain contains the catalytic domain which is structurally homologous to those of the other hemostatic serine proteases.

The mature factor is activated by the cleavage of the activation peptide by factor IXa (in the intrisic pathway), or by factor VIIa (in the extrinsic pathway). The activated factor then converts prothrombin to thrombin in the presence of factor Va, Ca+2, and phospholipid during blood clotting. Mutations of this gene result in factor X deficiency, a hemorrhagic condition of variable severity. Alternative splicing results in multiple transcript variants encoding different isoforms that may undergo similar proteolytic processing to generate mature polypeptides.

The Cleaved-Factor X/ Factor X LC (A41) Polyclonal Antibody is a highly specific and sensitive immunological reagent designed for the detection and quantification of Cleaved-Factor X/ Factor X LC in various biological samples.

This antibody is produced using high-quality polyclonal antibodies that have been purified and validated to ensure optimal performance and reproducibility. The Cleaved-Factor X/ Factor X LC (A41) Polyclonal Antibody is suitable for use in a wide range of applications, including Western blotting, immunohistochemistry, and ELISA.

It is an essential tool for researchers and clinicians working in the fields of coagulation, thrombosis, and hemostasis. With its exceptional specificity and sensitivity, this antibody is an indispensable tool for the accurate and reliable detection of Cleaved-Factor X/ Factor X LC in biological samples.