Cleaved-COL1A2 (G1102) Polyclonal Antibody

COL1A2 encodes the pro-alpha2 chain of type I collagen whose triple helix comprises two alpha1 chains and one alpha2 chain. Type I is a fibril-forming collagen found in most connective tissues and is abundant in bone, cornea, dermis and tendon. Mutations in this gene are associated with osteogenesis imperfecta types I-IV, Ehlers-Danlos syndrome type VIIB, recessive Ehlers-Danlos syndrome Classical type, idiopathic osteoporosis, and atypical Marfan syndrome. Symptoms associated with mutations in COL1A2, however, tend to be less severe than mutations in the gene for the alpha1 chain of type I collagen(COL1A1) reflecting the different role of alpha2 chains in matrix integrity. Three transcripts, resulting from the use of alternate polyadenylation signals, have been identified for COL1A2.

The Cleaved-COL1A2 (G1102) Polyclonal Antibody is a highly specific and sensitive tool designed for the detection and quantification of cleaved COL1A2 protein in various biological samples. This antibody has been meticulously developed and rigorously validated to ensure optimal performance and reliability.

The Cleaved-COL1A2 (G1102) Polyclonal Antibody exhibits exceptional affinity and selectivity towards the cleaved form of COL1A2, making it an ideal choice for researchers studying collagen metabolism and extracellular matrix remodeling. It recognizes a specific epitope within the cleaved region of COL1A2, enabling precise and accurate detection of this protein fragment.

This antibody has been extensively tested in a variety of experimental settings, including Western blotting, immunohistochemistry, and immunofluorescence. It consistently demonstrates robust and specific staining, allowing for reliable and reproducible results. Its high sensitivity ensures detection of even low levels of cleaved COL1A2, facilitating the analysis of subtle changes in protein expression.

The Cleaved-COL1A2 (G1102) Polyclonal Antibody is produced using state-of-the-art techniques and undergoes stringent quality control measures to guarantee batch-to-batch consistency and performance. It is supplied as a ready-to-use solution, eliminating the need for time-consuming and error-prone antibody preparation.

In summary, the Cleaved-COL1A2 (G1102) Polyclonal Antibody is a reliable and efficient tool for the detection and quantification of cleaved COL1A2 protein. Its exceptional specificity, sensitivity, and versatility make it an invaluable asset for researchers investigating collagen metabolism and extracellular matrix remodeling.