Cleaved-Caspase-6 p18 (D179) Polyclonal Antibody

CASP6 encodes a member of the cysteine-aspartic acid protease (caspase) family of enzymes. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic acid residues to produce two subunits, large and small, that dimerize to form the active enzyme.Caspase 6 is processed by caspases 7, 8 and 10, and is thought to function as a downstream enzyme in the caspase activation cascade. Alternative splicing of CASP6 results in multiple transcript variants that encode different isoforms.

The Cleaved-Caspase-6 p18 (D179) Polyclonal Antibody is a highly specific and sensitive tool designed for the detection and quantification of cleaved caspase-6 p18 protein in various biological samples. This antibody has been meticulously developed using advanced immunization techniques and exhibits exceptional affinity and selectivity towards the target protein.

Caspase-6 is a crucial enzyme involved in the execution phase of apoptosis, playing a pivotal role in cellular homeostasis and tissue development. The cleaved form of caspase-6, known as p18, is a reliable marker for the activation of caspase-6 and is widely used in research studies to investigate apoptotic pathways and cellular death mechanisms.

The Cleaved-Caspase-6 p18 (D179) Polyclonal Antibody demonstrates outstanding performance in various applications, including Western blotting, immunohistochemistry, and immunofluorescence. It exhibits minimal cross-reactivity with other caspase family members, ensuring accurate and specific detection of cleaved caspase-6 p18.

This antibody is produced using high-quality materials and undergoes rigorous quality control procedures to ensure batch-to-batch consistency and reproducibility. It is supplied as a liquid formulation, ready for immediate use, and is compatible with a wide range of experimental conditions and protocols.

Researchers and scientists can rely on the Cleaved-Caspase-6 p18 (D179) Polyclonal Antibody to provide reliable and precise results in their studies related to apoptosis, cellular death, and caspase-6 activation. Its exceptional sensitivity and specificity make it an indispensable tool for elucidating the intricate mechanisms underlying these processes.

Please note that this product is for research use only and is not intended for diagnostic or therapeutic purposes.