Cleaved-Caspase-5 p20 (D121) Polyclonal Antibody

CASP5 encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. Overexpression of the active form of caspase 5 induces apoptosis in fibroblasts. Max, a central component of the Myc/Max/Mad transcription regulation network important for cell growth, differentiation, and apoptosis, is cleaved by caspase 5; this process requires Fas-mediated dephosphorylation of Max. The expression of CASP5 is regulated by interferon-gamma and lipopolysaccharide. Alternatively spliced transcript variants have been identified for CASP5.

The Cleaved-Caspase-5 p20 (D121) Polyclonal Antibody is a highly specific and reliable tool designed for the detection and analysis of Cleaved-Caspase-5 p20 protein in various biological samples. This antibody has been meticulously developed using advanced techniques to ensure exceptional sensitivity and specificity.

Cleaved-Caspase-5 p20 is a crucial protein involved in the apoptotic pathway, playing a significant role in programmed cell death. This polyclonal antibody specifically recognizes the cleaved form of Caspase-5 p20, enabling precise identification and quantification of this protein in experimental settings.

The Cleaved-Caspase-5 p20 (D121) Polyclonal Antibody exhibits outstanding performance in a wide range of applications, including Western blotting, immunohistochemistry, and immunofluorescence. It has been extensively validated for its reliability and accuracy, providing researchers with reliable and reproducible results.

This antibody is produced using high-quality materials and undergoes rigorous quality control measures to ensure batch-to-batch consistency and optimal performance. It exhibits minimal cross-reactivity with other proteins, ensuring specific detection of Cleaved-Caspase-5 p20.

With its exceptional sensitivity and specificity, the Cleaved-Caspase-5 p20 (D121) Polyclonal Antibody is an indispensable tool for researchers studying apoptosis and related cellular processes. Its reliable performance and versatility make it an ideal choice for a wide range of research applications, contributing to the advancement of scientific knowledge in the field.