Cleaved-Caspase-4 p20 (Q81) Polyclonal Antibody

CASP4 encodes caspase 4 that is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes composed of a prodomain and a large and small protease subunit. Activation of caspases requires proteolytic processing at conserved internal aspartic residues to generate a heterodimeric enzyme consisting of the large and small subunits. This caspase is able to cleave and activate its own precursor protein, as well as caspase 1 precursor. When overexpressed, CASP4 induces cell apoptosis. Alternative splicing results in transcript variants encoding distinct isoforms.

The Cleaved-Caspase-4 p20 (Q81) Polyclonal Antibody is a highly specific and sensitive tool designed for the detection and quantification of Cleaved-Caspase-4 p20 protein in various biological samples. This antibody has been meticulously developed using advanced techniques to ensure exceptional performance and reliability.

Cleaved-Caspase-4 p20 is a crucial protein involved in the activation of the inflammatory response and the regulation of apoptosis. Its detection and analysis are of paramount importance in understanding the underlying mechanisms of various diseases, including cancer, neurodegenerative disorders, and autoimmune conditions.

This polyclonal antibody exhibits exceptional specificity towards Cleaved-Caspase-4 p20, enabling accurate and precise identification of the target protein. It has been rigorously validated through multiple experimental approaches, including Western blotting, immunohistochemistry, and immunofluorescence, ensuring its suitability for a wide range of applications.

The Cleaved-Caspase-4 p20 (Q81) Polyclonal Antibody demonstrates superior sensitivity, allowing for the detection of low-abundance Cleaved-Caspase-4 p20 protein levels. This attribute is particularly advantageous when working with limited sample quantities or when studying proteins expressed at low levels.

Furthermore, this antibody exhibits excellent reproducibility and consistency, ensuring reliable and robust results across multiple experiments. Its high affinity and avidity towards the target protein contribute to its exceptional performance, minimizing non-specific binding and background noise.

The Cleaved-Caspase-4 p20 (Q81) Polyclonal Antibody is supplied in a convenient and user-friendly format, facilitating ease of use and storage. It is provided as a liquid formulation, ready for immediate use, eliminating the need for time-consuming reconstitution steps.

In summary, the Cleaved-Caspase-4 p20 (Q81) Polyclonal Antibody is a highly reliable and sensitive tool for the detection and quantification of Cleaved-Caspase-4 p20 protein. Its exceptional specificity, sensitivity, and reproducibility make it an invaluable asset for researchers and scientists working in the fields of cell biology, immunology, and molecular biology.